Description
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | Semax (ACTH(4-7)PGP) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) |
| Molecular Weight | 813.93 Da (free base, monoisotopic) |
| CAS Number | 80714-61-0 |
| Salt Form | Acetate salt (lyophilised) |
| Primary Targets | MC4R (melanocortin-4 receptor); BDNF/TrkB; VEGF upregulation |
| Key Signalling | cAMP/PKA (MC4R); MAPK/ERK; PI3K/Akt (TrkB); BDNF upregulation |
| Research Classification | Neuropeptide; nootropic; neuroprotective; MC4R agonist |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | Core Research Peptide Pen v3 | Use with 4mm 31G pen needles |
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
Frequently Asked Questions
What is the difference between Semax and Selank in terms of mechanism?
The two peptides have complementary but distinct mechanisms and research applications.
Which Semax format suits in-vitro work?
The refill cartridge is made for the Core Research Peptide Pen v3 dispensing system. For cell-culture and other in-vitro assays the standard Semax 10mg vial is the usual choice, as it can be reconstituted in any appropriate buffer.
Is a Certificate of Analysis provided with each refill?
Yes. A batch-specific Certificate of Analysis documenting RP-HPLC purity, ESI-MS identity, LAL endotoxin result, and Karl Fischer moisture content is included with every Semax Refill 10mg order.
Related Research Guides
Standard Format
Semax 10mg — Full Vial
Related Refill
Selank Refill 10mg
Compatible Device
Reusable Metal Peptide Pen v3
Reconstitution
Bacteriostatic Water 10ml
Pen Needles
GlucoRx Pen Needles 4mm 31G
Category
All Refill Cartridges
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only — Not for Human or Veterinary Use
Semax Refill 10mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the Core Research Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
