Description
Semax 10mg — Product Identity and Format
Semax 10mg is a research-grade lyophilised preparation of Semax, a synthetic heptapeptide derived from the ACTH(4-7) fragment with a C-terminal Pro-Gly-Pro (PGP) extension. The full sequence is Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), corresponding to ACTH residues 4–7 with a C-terminal tripeptide extension designed to confer metabolic stability. Each vial supplied by Core Research contains 10mg of Semax, verified by RP-HPLC to ≥99.0% purity with identity confirmed by ESI-MS. Batch-specific analytical documentation is available through the Core Research CoA Portal.
Semax is distinct from ACTH itself and from other ACTH-derived fragments and analogues. The C-terminal PGP extension in Semax is not present in native ACTH and is a synthetic modification that increases resistance to enzymatic degradation. Semax should not be conflated with ACTH, α-MSH, or other melanocortin peptides in research documentation.
Compound Identity
| Attribute | Value | Notes |
|---|---|---|
| Common Name | Semax | ACTH(4-7)PGP; Met-Glu-His-Phe-Pro-Gly-Pro |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro | 7 amino acids; ACTH(4-7) core + C-terminal PGP extension; free N-terminus, free C-terminus (verify against CoA) |
| CAS Number | 80714-61-4 | Semax (free base); verify salt form against batch CoA |
| Molecular Formula | C37H51N9O10S | Free base |
| Molecular Weight | 813.9 Da | Free base (average) |
| Salt Form | Acetate | Research-grade lyophilised preparation; verify against batch CoA |
| Physical Form | White lyophilised powder | Research-grade preparation |
Analytical Specification
| Test Parameter | Method | Specification |
|---|---|---|
| Purity (RP-HPLC) | C18 column, UV 220 nm | ≥99.0% |
| Identity (ESI-MS) | Electrospray ionisation MS | ±0.1 Da of theoretical MW (814.9 Da [M+H]⁺) |
| Endotoxin (LAL) | Kinetic turbidimetric LAL | <1.0 EU/mg |
| Appearance | Visual inspection | White lyophilised powder |
Regional Medicinal Context — Separation from RUO Product
Semax has been registered as a medicinal product in Russia and some other post-Soviet states, where it has been used clinically in neurological contexts. This regional medicinal history is provided as factual background only and does not apply to the Core Research RUO material.
Neuroregulatory Signalling Research
These findings are relevant to research into neuropeptide signalling and the biology of growth factor regulation in the central nervous system. Refer to the Neuroregulatory Peptide Research Matrix for a comparative overview of neuroregulatory research peptides.
Storage and Transport
| Condition | Specification |
|---|---|
| Long-Term Storage | −20°C, protected from light and moisture |
| Stability Period | Stated on the batch-specific CoA |
| Transit | Ambient; cold-chain packaging included for applicable orders |
Batch Documentation
Every batch of Semax 10mg dispatched by Core Research is accompanied by a batch-specific Certificate of Analysis. CoA documents are available via the Certificate of Analysis Portal. For further information on neuroregulatory peptide research, refer to the Neuroregulatory Peptide Research Matrix and the Supplier Verification and Quality System.
Frequently Asked Questions
Is Semax the same as ACTH?
No. Semax is a synthetic heptapeptide derived from the ACTH(4-7) fragment with a C-terminal PGP extension. It is not ACTH(1-39) and does not have the steroidogenic activity of full-length ACTH. The ACTH(4-7) core sequence lacks the MC2R binding domain present in ACTH(1-24). Semax should not be described as ACTH or used as a substitute for ACTH in research applications.
Where can I access the Certificate of Analysis?
Batch-specific CoA documents are available via the Core Research CoA Portal.
Research Use Only. Semax 10mg is supplied by Core Research exclusively for in vitro laboratory research. Not for human or veterinary use. No dosing, administration, cognitive-enhancement, or neuroprotection guidance is provided.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only
Semax is supplied exclusively for in vitro laboratory research. Not for human or veterinary use. No dosing, reconstitution, or administration guidance is provided.
