Description
Tesamorelin Refill 10mg — Full-Length GHRH Analogue DPP-IV-Resistant Refill Cartridge for the Core Research Peptide Pen v3
The Tesamorelin Refill 10mg is a pre-filled lyophilised refill cartridge containing research-grade Tesamorelin, a synthetic analogue of human growth hormone-releasing hormone (GHRH) consisting of the full 44-amino-acid sequence of GHRH(1-44) with a trans-3-hexenoic acid modification at the N-terminus. This refill format is designed for direct use with the Core Research Reusable Metal Peptide Pen v3.
Each refill cartridge contains 10mg of lyophilised Tesamorelin acetate salt, verified by RP-HPLC to a minimum purity of ≥99.0%, with molecular identity confirmed by ESI-MS. Endotoxin content is certified at <1.0 EU/mg by kinetic turbidimetric LAL assay. A batch-specific Certificate of Analysis is included with every order.
Tesamorelin is the most extensively characterised full-length GHRH analogue in pre-clinical and clinical research, with a well-defined mechanism of action at the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells.
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | Tesamorelin (trans-3-hexenoic acid-GHRH(1-44)) |
| Structure | Full 44-aa GHRH sequence + N-terminal trans-3-hexenoic acid modification |
| Molecular Weight | 5,135.88 Da (free base, monoisotopic) |
| CAS Number | 218949-48-5 |
| Salt Form | Acetate salt (lyophilised) |
| DPP-IV Resistance | N-terminal trans-3-hexenoic acid blocks DPP-IV cleavage at His-Ala bond |
| Primary Receptor | GHRHR (GHRH receptor) — full-length agonist |
| Key Signalling | cAMP/PKA/CREB; intracellular Ca²⁺ mobilisation; GH synthesis and secretion |
| Research Classification | Full-length GHRH analogue; GH axis stimulation; visceral adiposity research |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | Core Research Peptide Pen v3 | Use with 4mm 31G pen needles |
Reconstitution & Handling Guidance
Tesamorelin Refill cartridges are supplied in lyophilised form and must be reconstituted before use. For use with the Core Research Peptide Pen v3, reconstitute the cartridge with bacteriostatic water to the desired concentration. A typical reconstitution is 2ml bacteriostatic water per 10mg cartridge to yield a 5mg/ml solution. Allow the lyophilised cake to dissolve completely by gentle swirling — do not vortex. The reconstituted solution should be clear and colourless; discard if particulate matter or discolouration is observed.
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
Frequently Asked Questions
How does Tesamorelin differ from CJC-1295 in terms of GHRHR engagement?
Tesamorelin is the full 44-amino-acid sequence of GHRH with an N-terminal DPP-IV-resistant modification, engaging the full binding interface of GHRHR. CJC-1295 corresponds only to GHRH residues 1-29 and therefore engages a subset of the GHRHR binding interface. For studies requiring full GHRHR pharmacology, Tesamorelin is the more appropriate research tool.
Is a Certificate of Analysis provided with each refill?
Yes. A batch-specific Certificate of Analysis documenting RP-HPLC purity, ESI-MS identity, LAL endotoxin result, and Karl Fischer moisture content is included with every Tesamorelin Refill 10mg order.
Related Research Guides
Standard Format
Tesamorelin 10mg — Full Vial
Related Refill
CJC / Ipamorelin Refill 10mg
Compatible Device
Reusable Metal Peptide Pen v3
Reconstitution
Bacteriostatic Water 10ml
Pen Needles
GlucoRx Pen Needles 4mm 31G
Category
All Refill Cartridges
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only — Not for Human or Veterinary Use
Tesamorelin Refill 10mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the Core Research Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
