Description
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | Melanotan I (MT-1, Afamelanotide) |
| Sequence | [Nle4, D-Phe7]-α-MSH (13 amino acids) |
| Molecular Weight | 1,646.87 Da (free base, monoisotopic) |
| CAS Number | 75921-69-6 |
| Salt Form | Acetate salt (lyophilised) |
| Receptor Selectivity | MC1R selective (>1,000-fold affinity vs native α-MSH at MC1R) |
| Key Signalling | cAMP/PKA/MITF/TYR melanogenesis pathway; anti-apoptotic signalling |
| Research Classification | Selective MC1R agonist; melanogenesis; photoprotection; pigmentation research |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | Core Research Peptide Pen v3 | Use with 4mm 31G pen needles |
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
Frequently Asked Questions
What is the difference between MT-1 (Melanotan I) and MT-2 (Melanotan II)?
MT-2 (Melanotan II) is a cyclic 7-amino-acid analogue that is a pan-agonist at MC1R–MC5R, with significant activity at MC3R and MC4R in addition to MC1R. Researchers studying MC1R-specific melanogenesis and photoprotection should use MT-1; researchers studying multi-receptor melanocortin pharmacology should use MT-2.
Is MT-1 associated with the same side effects as MT-2 in pre-clinical models?
Is a Certificate of Analysis provided with each refill?
Yes. A batch-specific Certificate of Analysis documenting RP-HPLC purity, ESI-MS identity, LAL endotoxin result, and Karl Fischer moisture content is included with every MT-1 Refill 10mg order.
Related Research Guides
Standard Format
Melanotan I (MT-1) 10mg — Full Vial
Related Refill
MT-2 Refill 10mg
Compatible Device
Reusable Metal Peptide Pen v3
Reconstitution
Bacteriostatic Water 10ml
Pen Needles
GlucoRx Pen Needles 4mm 31G
Category
All Refill Cartridges
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only — Not for Human or Veterinary Use
MT-1 Refill 10mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the Core Research Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
