Description
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | Melanotan II (MT-2) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic heptapeptide) |
| Molecular Weight | 1,024.18 Da (free base, monoisotopic) |
| CAS Number | 121062-08-6 |
| Salt Form | Acetate salt (lyophilised) |
| Receptor Activity | Pan-agonist: MC1R, MC3R, MC4R, MC5R (high affinity); MC2R (low affinity) |
| Key Signalling | cAMP/PKA at all MC receptors; MC4R-mediated energy homeostasis; MC1R-mediated melanogenesis |
| Research Classification | Pan-melanocortin agonist; pigmentation; energy homeostasis; appetite research |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | Core Research Peptide Pen v3 | Use with 4mm 31G pen needles |
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
Frequently Asked Questions
What distinguishes MT-2 from MT-1 in terms of receptor selectivity?
MT-2 is a pan-agonist at MC1R–MC5R with high affinity at MC1R, MC3R, and MC4R.
Why does MT-2 have a cyclic structure while MT-1 is linear?
MT-1’s linear structure retains the full 13-amino-acid sequence of α-MSH with [Nle4, D-Phe7] substitutions, providing MC1R selectivity through a different structural approach.
Is a Certificate of Analysis provided with each refill?
Yes. A batch-specific Certificate of Analysis documenting RP-HPLC purity, ESI-MS identity, LAL endotoxin result, and Karl Fischer moisture content is included with every MT-2 Refill 10mg order.
Related Research Guides
Standard Format
Melanotan II (MT-2) 10mg — Full Vial
Related Refill
MT-1 Refill 10mg
Compatible Device
Reusable Metal Peptide Pen v3
Reconstitution
Bacteriostatic Water 10ml
Pen Needles
GlucoRx Pen Needles 4mm 31G
Category
All Refill Cartridges
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only — Not for Human or Veterinary Use
MT-2 Refill 10mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the Core Research Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
