Description
Melanotan I (MT1) 10mg — Product Identity and Format
MT1 is a 13-amino-acid peptide with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, incorporating Nle⁴ and D-Phe⁷ substitutions relative to native α-MSH. Each vial supplied by Core Research contains 10mg of MT1, verified by RP-HPLC to ≥99.0% purity with identity confirmed by ESI-MS. Batch-specific analytical documentation is available through the Core Research CoA Portal.
MT1 is a linear peptide and is structurally distinct from Melanotan II (MT2), which is a cyclic heptapeptide. MT1 and MT2 differ in sequence, cyclisation state, molecular weight, receptor selectivity profile, and published research contexts. They are not interchangeable in research applications. The structural and receptor-profile differences between MT1 and MT2 are detailed in the Melanotan I vs Melanotan II Laboratory Comparison guide.
Compound Identity
| Attribute | Value | Notes |
|---|---|---|
| Common Names | Melanotan I, MT1, Afamelanotide | Linear α-MSH analogue; distinct from MT2 (cyclic heptapeptide) |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ | 13 amino acids; N-terminal acetyl; C-terminal amide; Nle⁴, D-Phe⁷ substitutions vs native α-MSH |
| CAS Number | 75921-69-6 | Afamelanotide (free base) |
| Molecular Formula | C78H111N21O19 | Free base |
| Molecular Weight | 1,646.8 Da | Free base (average) |
| Salt Form | Acetate | Research-grade lyophilised preparation; verify against batch CoA |
| Receptor Context | MC1R, MC3R, MC4R, MC5R | Binding affinity data from preclinical models; not selective for a single MCR subtype |
| Physical Form | White lyophilised powder | Research-grade preparation |
Analytical Specification
| Test Parameter | Method | Specification |
|---|---|---|
| Purity (RP-HPLC) | C18 column, UV 220 nm | ≥99.0% |
| Identity (ESI-MS) | Electrospray ionisation MS | Multiply-charged ions confirmed; ±0.1 Da of theoretical MW |
| Endotoxin (LAL) | Kinetic turbidimetric LAL | <1.0 EU/mg |
| Appearance | Visual inspection | White lyophilised powder |
Structural Comparison with MT2 and Native α-MSH
MT1 and MT2 are structurally distinct compounds. MT1 is a linear 13-amino-acid peptide; MT2 is a cyclic 7-amino-acid peptide. They differ in sequence, cyclisation state, molecular weight, receptor selectivity profile, and published research contexts. Research comparing MT1 and MT2 receptor pharmacology is relevant to understanding the structural basis of melanocortin receptor selectivity. Refer to the Melanotan I vs Melanotan II Laboratory Comparison and the Melanocortin Receptor Research Matrix for detailed comparisons.
Storage and Transport
| Condition | Specification |
|---|---|
| Long-Term Storage | −20°C, protected from light and moisture |
| Stability Period | Stated on the batch-specific CoA |
| Transit | Ambient; cold-chain packaging included for applicable orders |
Batch Documentation
Every batch of MT1 10mg dispatched by Core Research is accompanied by a batch-specific Certificate of Analysis. CoA documents are available via the Certificate of Analysis Portal. For further information on melanocortin receptor research, refer to the Melanocortin Receptor Research Matrix and the Melanotan I vs Melanotan II Laboratory Comparison.
Frequently Asked Questions
What is the difference between MT1 and MT2?
MT1 (afamelanotide) is a linear 13-amino-acid α-MSH analogue (MW 1,646.8 Da). MT2 (melanotan II) is a cyclic 7-amino-acid peptide (MW 1,024.2 Da). They differ in sequence, cyclisation state, molecular weight, and receptor selectivity profile. MT2 has higher selectivity for MC3R and MC4R relative to MT1. They are not interchangeable in research applications.
Where can I access the Certificate of Analysis?
Batch-specific CoA documents are available via the Core Research CoA Portal.
Research Use Only. Melanotan I (MT1) 10mg is supplied by Core Research exclusively for in vitro laboratory research. Not for human or veterinary use.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only
Melanotan I (MT1) is supplied exclusively for in vitro laboratory research. Not for human or veterinary use. No dosing, reconstitution, tanning, or administration guidance is provided.
