Description
Melanotan II (MT2) 10mg — Product Identity and Format
Melanotan II (MT2) 10mg is a research-grade lyophilised preparation of a cyclic synthetic melanocortin analogue. MT2 has the sequence Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, where the cyclic structure is formed by a lactam bridge between the Asp and Lys side chains. This cyclic heptapeptide structure confers a distinct receptor selectivity profile compared to the linear α-MSH analogue MT1 (afamelanotide). Each vial supplied by Core Research contains 10mg of MT2, verified by RP-HPLC to ≥99.0% purity with identity confirmed by ESI-MS. Batch-specific analytical documentation is available through the Core Research CoA Portal.
MT2 is structurally distinct from MT1 and from PT-141 (bremelanotide). MT2 is a cyclic heptapeptide; MT1 is a linear tridecapeptide; PT-141 is a cyclic heptapeptide with a C-terminal hydroxyl group instead of the C-terminal amide present in MT2. These structural differences result in distinct receptor selectivity profiles and published research contexts. MT2, MT1, and PT-141 are not interchangeable in research applications.
Compound Identity
| Attribute | Value | Notes |
|---|---|---|
| Common Name | Melanotan II, MT2 | Cyclic melanocortin analogue; distinct from linear MT1 and from PT-141 |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ | 7 amino acids; cyclic via Asp-Lys lactam bridge; N-terminal acetyl-Nle; C-terminal amide |
| CAS Number | 121062-08-6 | Melanotan II (free base); verify salt form against batch CoA |
| Molecular Formula | C50H69N15O9 | Free base (cyclic) |
| Molecular Weight | 1,024.2 Da | Free base (average) |
| Salt Form | Acetate | Research-grade lyophilised preparation; verify against batch CoA |
| Receptor Context | MC1R, MC3R, MC4R, MC5R | Higher relative affinity for MC3R and MC4R vs MT1; verify against published binding data for specific experimental context |
| Physical Form | White lyophilised powder | Research-grade preparation |
Analytical Specification
| Test Parameter | Method | Specification |
|---|---|---|
| Purity (RP-HPLC) | C18 column, UV 220 nm | ≥99.0% |
| Identity (ESI-MS) | Electrospray ionisation MS | ±0.1 Da of theoretical MW (1,025.2 Da [M+H]⁺) |
| Endotoxin (LAL) | Kinetic turbidimetric LAL | <1.0 EU/mg |
| Appearance | Visual inspection | White lyophilised powder |
Storage and Transport
| Condition | Specification |
|---|---|
| Long-Term Storage | −20°C, protected from light and moisture |
| Stability Period | Stated on the batch-specific CoA |
| Transit | Ambient; cold-chain packaging included for applicable orders |
Batch Documentation
Every batch of MT2 10mg dispatched by Core Research is accompanied by a batch-specific Certificate of Analysis. CoA documents are available via the Certificate of Analysis Portal. For further information on melanocortin receptor research, refer to the Melanocortin Receptor Research Matrix.
Frequently Asked Questions
What is the difference between MT2 and MT1?
MT2 (Melanotan II) is a cyclic heptapeptide (MW 1,024.2 Da, CAS 121062-08-6). MT1 (afamelanotide) is a linear tridecapeptide (MW 1,646.8 Da, CAS 75921-69-6). They differ in sequence, cyclisation state, molecular weight, and receptor selectivity profile. MT2 has higher relative affinity for MC3R and MC4R compared to MT1. They are not interchangeable in research applications.
Where can I access the Certificate of Analysis?
Batch-specific CoA documents are available via the Core Research CoA Portal.
Research Use Only. Melanotan II (MT2) 10mg is supplied by Core Research exclusively for in vitro laboratory research. Not for human or veterinary use.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only
Melanotan II (MT2) is supplied exclusively for in vitro laboratory research. Not for human or veterinary use. No dosing, reconstitution, tanning, or administration guidance is provided.
