Description
5-Amino-1MQ 50mg — Product Identity and Format
NNMT catalyses the methylation of nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosylmethionine (SAM) as the methyl donor.
Each vial supplied by Core Research contains 50mg of 5-Amino-1MQ supplied as the iodide salt, verified by HPLC to ≥99.0% purity with identity confirmed by LC-MS. Batch-specific analytical documentation is available through the Core Research CoA Portal.
Compound Identity
| Attribute | Value | Notes |
|---|---|---|
| Common Name | 5-Amino-1MQ | 5-amino-1-methylquinolinium |
| IUPAC Name | 5-amino-1-methylquinolin-1-ium | Quaternary ammonium cation |
| CAS Number | 2765-11-9 | 5-Amino-1-methylquinolinium iodide (iodide salt form) |
| Molecular Formula (cation) | C10H10N2+ | Free base cation; iodide salt formula: C10H10IN2 |
| Molecular Weight | 158.2 Da (cation); 285.1 Da (iodide salt) | Verify against batch CoA for the supplied form |
| Primary Biochemical Target | NNMT (Nicotinamide N-methyltransferase) | Competitive inhibitor; inhibition constant stated on batch CoA |
| Cell Permeability | Yes — freely cell-permeable | No carrier or transfection required in cell-based models |
| Physical Form | Crystalline powder | Off-white to pale yellow solid |
Salt form note: CAS 2765-11-9 refers to the iodide salt of 5-amino-1-methylquinolinium. Researchers should verify the exact supplied salt form and the applicable molecular weight against the batch-specific Certificate of Analysis before use in quantitative experiments.
Analytical Specification
| Test Parameter | Method | Specification |
|---|---|---|
| Purity (HPLC) | C18 column, UV 254 nm | ≥99.0% |
| Identity (LC-MS) | LC-MS/MS | Confirmed against theoretical MW (cation m/z 159.1) |
| Identity (NMR) | ¹H NMR (400 MHz) | Consistent with 5-amino-1-methylquinolinium structure |
| Residual Solvents | GC headspace analysis | ICH Q3C limits |
| Appearance | Visual inspection | Off-white to pale yellow crystalline powder |
Storage and Transport
| Condition | Specification |
|---|---|
| Long-Term Storage | −20°C, protected from light and moisture |
| Stability Period | Stated on the batch-specific CoA |
| Transit | Ambient; cold-chain packaging included for applicable orders |
Batch Documentation and CoA
Every batch of 5-Amino-1MQ 50mg dispatched by Core Research is accompanied by a batch-specific Certificate of Analysis documenting HPLC purity, LC-MS identity, NMR confirmation, and residual solvent results. CoA documents are available via the Certificate of Analysis Portal.
Frequently Asked Questions
What is the exact chemical form supplied?
5-Amino-1MQ is supplied as the iodide salt (CAS 2765-11-9: 5-amino-1-methylquinolinium iodide). The free base cation formula is C₁₀H₁₀N₂⁺ (MW 158.2 Da); the iodide salt formula is C₁₀H₁₀IN₂ (MW 285.1 Da). Researchers should verify the exact supplied form and applicable molecular weight against the batch-specific CoA before use in quantitative experiments.
Where can I access the Certificate of Analysis?
Batch-specific CoA documents are available via the Core Research CoA Portal. Each CoA documents the HPLC purity result, LC-MS identity confirmation, NMR data, and residual solvent analysis for the specific batch supplied.
Research Use Only. 5-Amino-1MQ 50mg is supplied by Core Research exclusively for in vitro laboratory research by qualified investigators. Not for human or veterinary use. No dosing, administration, weight-management, or supplementation guidance is provided.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only
5-Amino-1MQ is supplied exclusively for in vitro laboratory research. Not for human or veterinary use. No dosing, reconstitution, or administration guidance is provided.
