Description
Each 10mg vial is accompanied by a batch-specific Certificate of Analysis.
Analytical Specification
| Parameter | Specification |
|---|---|
| Sequence (single-letter) | Lys-Pro-Val (KPV) |
| Parent Protein | Alpha-melanocyte-stimulating hormone (α-MSH), residues 11–13 |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.44 Da (free base) |
| CAS Number | 69661-02-5 |
| Salt Form | Acetate |
| Physical Form | White to off-white lyophilised powder |
| Purity (HPLC) | ≥99.0% |
| Identity Confirmation | ESI-MS (observed vs. theoretical monoisotopic mass) |
| Fill per Vial | 10mg |
Storage and Transport Conditions
| Condition | Specification | Notes |
|---|---|---|
| Lyophilised (sealed) | −20°C, desiccated | Store in original sealed vial until use; protect from light and moisture |
| Transit | Ambient; cold-chain packaging included | Lyophilised form is stable during standard UK domestic shipping |
Note: Reconstituted solution storage, solvent selection, and working concentration guidance are not provided, consistent with Core Research’s Research Use Only supply policy. Researchers should refer to their institutional SOPs and the published literature for handling reconstituted peptide solutions.
Batch Documentation
Every batch of KPV dispatched by Core Research is accompanied by a batch-specific Certificate of Analysis (CoA) confirming HPLC purity and ESI-MS identity. CoA documents are available via the Certificate of Analysis Portal. For further information on our analytical methodology, refer to the guide on HPLC Purity in Peptide Research.
Analytical Note — Core Research Quality Team
KPV is a low-molecular-weight tripeptide (342.44 Da) and is characterised by reversed-phase HPLC with UV detection at 214 nm, consistent with peptide bond absorbance. ESI-MS identity confirmation is performed against the theoretical monoisotopic mass of the free base. The acetate salt form is standard for lyophilised research-grade peptides and does not alter the primary sequence or molecular identity of the compound.
Structural Identity and Relationship to α-MSH
Alpha-MSH is a 13-amino-acid peptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) produced by POMC processing in the pituitary and peripheral tissues.
A key finding in the characterisation of KPV’s cellular uptake is the role of the intestinal di/tripeptide transporter PepT1 (SLC15A1).
Regulatory and Compliance Status
KPV is not approved as a medicinal product in the United Kingdom, European Union, or United States. It is not listed as a controlled substance under the Misuse of Drugs Act 1971 or the Psychoactive Substances Act 2016. Supply by Core Research is made strictly under research-use-only (RUO) conditions. Purchasers are responsible for ensuring compliance with all applicable national and institutional regulations governing the procurement, storage, and use of research compounds. For the full supply boundary, refer to the RUO Compliance Policy.
Frequently Asked Questions
What is the molecular weight of KPV?
KPV (Lys-Pro-Val, free base) has a molecular weight of 342.44 Da and the molecular formula C16H30N4O4. Core Research supplies KPV as the acetate salt in lyophilised form. CAS number: 69661-02-5.
Is a Certificate of Analysis provided?
Yes. Every vial dispatched by Core Research is accompanied by a batch-specific CoA confirming HPLC purity (≥99.0%) and ESI-MS identity. Documents are accessible via the CoA Portal.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
Research Use Only — Not for Human or Veterinary Use
KPV is supplied exclusively for in vitro and pre-clinical laboratory research. It is not a medicinal product, has not been approved for therapeutic use in any jurisdiction, and must not be administered to humans or animals. Procurement confirms the purchaser is a qualified researcher operating within an institutional or commercial laboratory setting.
