Description
Compound Identity & Molecular Data
| Parameter | Value |
|---|---|
| Compound Name | KPV (Lys-Pro-Val) |
| Sequence | Lys-Pro-Val (C-terminal tripeptide of α-MSH, residues 11–13) |
| Molecular Formula | C₁₅H₂₉N₃O₄ |
| Molecular Weight | 342.44 Da (free base) |
| CAS Number | 13147-12-1 |
| Salt Form | Acetate salt (lyophilised) |
| Primary Receptors | MC1R, MC3R (melanocortin receptors) |
| Key Signalling | NF-κB inhibition; TNF-α, IL-1β, IL-6, IL-8 suppression |
| Research Classification | Anti-inflammatory tripeptide; antimicrobial; mucosal healing |
Analytical Release Testing — Refill Cartridge Specification
| Test | Method | Specification | Notes |
|---|---|---|---|
| Purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Acetonitrile/water gradient; TFA modifier |
| Identity | ESI-MS | Confirmed ±0.1 Da | Electrospray ionisation mass spectrometry |
| Endotoxin | Kinetic turbidimetric LAL | <1.0 EU/mg | USP <85> compliant method |
| Residual Moisture | Karl Fischer titration | <5.0% | Coulometric KF; lyophilisation quality indicator |
| Quantity per Cartridge | Gravimetric | Per label ± 5% | Lyophilised acetate salt; net peptide content |
| Compatible Device | — | Core Research Peptide Pen v3 | Use with 4mm 31G pen needles |
Reconstitution & Handling Guidance
KPV Refill cartridges are supplied in lyophilised form and must be reconstituted before use. For use with the Core Research Peptide Pen v3, reconstitute the cartridge with bacteriostatic water to the desired concentration. A typical reconstitution is 2ml bacteriostatic water per 10mg cartridge to yield a 5mg/ml solution. Allow the lyophilised cake to dissolve completely by gentle swirling — do not vortex. The reconstituted solution should be clear and colourless; discard if particulate matter or discolouration is observed.
Storage & Stability
| Condition | Temperature | Duration | Notes |
|---|---|---|---|
| Lyophilised cartridge (long-term) | −20°C | ≥24 months | Desiccated; protect from light and moisture |
| Lyophilised cartridge (short-term) | 2–8°C | Up to 4 weeks | Desiccated; suitable for active research use |
| Reconstituted in bacteriostatic water | 2–8°C | Up to 28 days | Benzyl alcohol preservative extends stability |
| Reconstituted aliquots (extended) | −80°C | Up to 12 months | Single-use aliquots; avoid repeated freeze-thaw cycles |
Frequently Asked Questions
What is the minimum effective concentration of KPV in cell culture models?
Does KPV have melanotropic activity like full-length α-MSH?
No. KPV lacks the His-Phe-Arg-Trp core sequence (residues 6–9 of α-MSH) that is responsible for the melanotropic activity of the parent peptide.
Is a Certificate of Analysis provided with each refill?
Yes. A batch-specific Certificate of Analysis documenting RP-HPLC purity, ESI-MS identity, LAL endotoxin result, and Karl Fischer moisture content is included with every KPV Refill 10mg order.
Related Research Guides
Standard Format
KPV 10mg — Full Vial
Complementary Refill
BPC-157 Refill 10mg
Compatible Device
Reusable Metal Peptide Pen v3
Reconstitution
Bacteriostatic Water 10ml
Pen Needles
GlucoRx Pen Needles 4mm 31G
Category
All Refill Cartridges
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
For Research Use Only — Not for Human or Veterinary Use
KPV Refill 10mg is supplied exclusively for in vitro and pre-clinical in vivo research use with the Core Research Reusable Metal Peptide Pen v3. This product has not been evaluated by the MHRA, FDA, or any other regulatory authority for safety or efficacy in humans or animals. Purchase confirms the buyer is a qualified researcher.
