Description
BPC-157 / TB-500 Refill 10mg — Product Identity & Format Specification
The BPC-157 / TB-500 Refill 10mg is a replacement cartridge for compatible Core Research dispensing pen devices, containing a lyophilised blend of two structurally and mechanistically distinct research peptides: BPC-157 (stable gastric pentadecapeptide, sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) and TB-500 (synthetic analogue of the active fragment of thymosin beta-4, sequence Ac-LKKTETQ). Each refill cartridge contains a total nominal mass of 10 mg of the combined peptide blend, supplied as a lyophilised powder within a sealed cartridge. The refill format allows researchers to reload a compatible pen device without replacing the full pen body, supporting cost-effective and sustainable laboratory dispensing workflows.
| Attribute | BPC-157 Component | TB-500 Component |
|---|---|---|
| Full Name | Stable Gastric Pentadecapeptide BPC-157 | TB-500 (Thymosin Beta-4 Fragment Ac-LKKTETQ) |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val | Ac-Lys-Lys-Thr-Glu-Thr-Gln (heptapeptide) |
| CAS Number | 137525-51-0 | 77591-33-4 |
| Molecular Weight | 1419.5 g/mol | 887.0 g/mol |
| Molecular Formula | C62H98N16O22 | C38H68N10O14 |
| Origin | Synthetic; derived from human gastric juice protein BPC | Synthetic; derived from thymosin beta-4 (Tβ4) actin-binding domain |
| Pen Format Attribute | Value |
|---|---|
| Product Format | Replacement cartridge (lyophilised; compatible with Core Research pen devices) |
| Total Nominal Mass | 10 mg (combined BPC-157 + TB-500 blend) |
| Physical Form | Lyophilised powder within sealed cartridge |
| Salt Form | Acetate |
| Purity (HPLC) | ≥99.0% (each component verified independently) |
| Identity Confirmation | ESI-MS for each component; characteristic molecular ions confirmed |
| Endotoxin | <1 EU/mg |
| Dispensing Increment | Calibrated per batch; refer to batch CoA for volume-per-increment specification |
| Cartridge Capacity | Declared on batch label |
| Storage (pen, sealed) | −20 °C, desiccated, protected from light; stable ≥24 months from manufacture date |
| Storage (pen, in use) | 2–8 °C after first use; use within 30 days; do not freeze once reconstituted |
| Documentation | Batch-specific Certificate of Analysis (compound CoA + finished-format CoA) available on request |
| Intended Use | Controlled laboratory dispensing; in vitro and laboratory research only (RUO) |
Analytical Quality & Batch Documentation
Each batch of the BPC-157 / TB-500 Refill 10mg undergoes a two-tier analytical release process. Both peptide components are verified independently at the bulk compound stage before blending, and the finished pen format is subject to a separate quality release covering dispensing accuracy, cartridge integrity, and endotoxin testing. The compound-level Certificate of Analysis (CoA) documents HPLC purity chromatograms, ESI-MS spectra, and lot numbers for each component. The finished-format CoA documents the assembled pen batch, dispensing increment calibration, and endotoxin result.
| Test | Method | Specification | Stage |
|---|---|---|---|
| BPC-157 purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Compound |
| TB-500 purity | RP-HPLC (C18, UV 220 nm) | ≥99.0% | Compound |
| BPC-157 identity | ESI-MS; MW 1419.5 g/mol | ±0.5 Da | Compound |
| TB-500 identity | ESI-MS; MW 887.0 g/mol | ±0.5 Da | Compound |
| Endotoxin | LAL (limulus amebocyte lysate) | <1 EU/mg | Finished format |
| Dispensing accuracy | Gravimetric calibration | Per batch specification | Finished format |
| Cartridge integrity | Visual + pressure test | No leakage; intact seal | Finished format |
| Water content | Karl Fischer titration | ≤5.0% | Compound |
Researchers should record the lot numbers from both CoA documents against experimental data to maintain full traceability from raw compound through to finished dispensing format. The dispensing increment specification on the batch CoA is essential for calculating the mass of blend delivered per actuation in quantitative research protocols.
BPC-157: Pentadecapeptide Research Profile
BPC-157 (stable gastric pentadecapeptide) is a synthetic 15-amino acid sequence derived from the human gastric juice protein BPC.
TB-500: Thymosin Beta-4 Fragment Research Profile
TB-500 is a synthetic heptapeptide (Ac-LKKTETQ) corresponding to the actin-binding domain of thymosin beta-4 (Tβ4), a 43-amino acid endogenous peptide produced by the thymus and platelets.
Refill Cartridge Format, Storage & Laboratory Handling
The BPC-157 / TB-500 Refill 10mg is supplied as a sealed replacement cartridge containing the lyophilised peptide blend. The cartridge is designed for use with compatible Core Research pen dispensing devices. Researchers should confirm cartridge compatibility with their pen device model before use; refer to the pen device documentation for installation instructions.
| Condition | Guidance |
|---|---|
| Sealed cartridge storage | −20 °C in a desiccated environment, protected from light; stable ≥24 months from manufacture date |
| Transport | Ambient temperature acceptable for short transit (<72 hours); cold-chain recommended for extended transit |
| Reconstitution solvent | Sterile water for injection (WFI) or bacteriostatic water; volume per batch CoA specification |
| In-use storage | 2–8 °C after first use; use within 30 days; do not freeze once reconstituted |
| Dispensing | Use calibrated dispensing increment per batch CoA; record actuation count for mass tracking |
| Compatibility | Compatible with standard aqueous research buffers; avoid high-temperature exposure after reconstitution |
| Device inspection | Inspect pen body and cartridge for physical damage before use; do not use if seal is compromised |
| Disposal | Dispose of pen and cartridge in accordance with local laboratory waste regulations for research peptides |
Researchers should handle the pen device in accordance with standard laboratory safety protocols for research-grade peptides. The refill cartridge is a single-use laboratory research component and must not be used outside its intended laboratory dispensing application. Personal protective equipment (gloves, lab coat, eye protection) is recommended during reconstitution and dispensing operations.
Research Use Only — Legal Notice
The BPC-157 / TB-500 Blend 10mg Pen is supplied strictly for in vitro laboratory and research use only. It must not be administered to humans or animals. The pen format is a laboratory dispensing device and is not a medical device or injection pen. Purchase, possession, and use are subject to applicable UK and international regulations governing research chemicals. Core Research accepts no liability for misuse of this product outside its intended research application.
Research context
The published literature on this material is summarised in the laboratory guides linked below. This record describes the material as supplied: identity, format, analytics, storage and documentation. It does not describe effects, and none should be inferred from the catalogue category.
